A model that might better explain the effects of addiction substances on the nervous system: the CoBBGlum model
نویسندگان
چکیده
Background The effect of addictive substances on brain’s utilizing mechanisms of glucose for neuronal functions are poorly understood. To identify novel neurobiological mechanisms of addiction (precisely on brain glucose metabolism), we developed a model that incorporates the b-cell and the fishbone models of glucose metabolism and examined the role of various psychostimulants (alcohol, cocaine, heroine) on the functions of the model. The abbreviation “CoBBGluM model” means Convergence (incorporation of the b-cell and the fishbone models) model of Blood-Brain Glucose Metabolism.
منابع مشابه
Modeling the effect of addiction on social wellfare of society with an emphasis on health: Case Study of Iran
Introduction: Drug abuse has imposed high economic and social costs through its destructive effects on people 's health and increased crime and mortality.This affects the social welfare through the impact on the health of the consumer. Therefore, the main purpose of this study is to model the effects of addiction on social wellfare with an emphasis on health in Iran. Method:this study is a d...
متن کاملEffect of simvastatin on memory disorders and Hippocampal cell death in the model of the fetal alcoholic syndrome in male rats
Introduction: Exposure to ethanol as a neurotratogen in the developmental period has destructive effects on the central nervous system and causes neurological disorders in adulthood. These disorders are associated with apoptosis in areas of the brain such as the hippocampus, by activating the oxidative-inflammatory cascade and high levels of nerve degeneration. Simvastatin, used as a drug to tr...
متن کاملNot Up for Discussion: Applying Lukes’ Power Model to the Study of Health System Corruption; Comment on “We Need to Talk About Corruption in Health Systems”
This companion paper suggests the potential benefits of applying Steven Lukes’ dimensions of power model to the study of corruption in health systems. Lukes’ model sets out three “faces of power” classified by their influence on political discourse, resulting in overt, covert and latent discussion of issues depending on the degree of their alignment with the agenda of d...
متن کاملTherapeutic effects of rosemary (Rosmarinus officinalis L.) and its active constituents on nervous system disorders
Rosemary (Rosmarinus officinalis L.) is an evergreen bushy shrub which grows along the Mediterranean Sea, and sub-Himalayan areas. In folk medicine, it has been used as an antispasmodic, mild analgesic, to cure intercostal neuralgia, headaches, migraine, insomnia emotional upset, and depression. Different investigations have highlighted rosemary neuropharmacological properties as their main top...
متن کاملEffects of Co-Administration of Bone Marrow Stromal Cells and L-Carnitine on The Recovery of Damaged Ovaries by Performing Chemotherapy Model in Rat
Objective Chemotherapy may damage ovaries. L-carnitine (LC) as a type of flavonoid antioxidants and bone marrow stromal cells (BMSCs) as a type of mesenchymal stem cells may recover damaged ovaries. It seems that LC has favorable effects on differentiation, increasing lifespan and decreasing apoptosis in BMSCs. The aim of this study was to investigate the effects of co-administration of BMSCs a...
متن کامل